We may think of music as physical, a series of audible sounds performed or encoded into a recorded medium. But music is trans-dimensional, traversing the physical and non-physical realms, with the power to affect soul, body, and mind. Music can transform substances through resonance, making it a conductor of human biology, physical matter, and the human psyche. To understand the concept of resonance, we need to understand what music is at a fundamental level. This article explores music and its interpersonal connection through resonance, an understanding that changes our conception of music’s nature and effect.